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Expression of Concern regarding Sudbo et al., N Engl J Med 2001;344(17):1270-1278.

Expression of Concern regarding Sudbø et al., N Engl J Med 2004;350(14):1405-1413.

Editorial
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Volume 354:638 February 9, 2006 Number 6
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Expression of Concern: Sudbø J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13
Gregory D. Curfman, M.D., Stephen Morrissey, Ph.D., and Jeffrey M. Drazen, M.D.

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 by Curfman, G. D.

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In the issue of April 26, 2001, we published a study by Jon Sudbø et al.1 Figures 3B and 3C of that article, which purport to represent two different patients and stages of oral epithelial dysplasia, are in fact different magnifications of the same photomicrograph. Because the results of another study by Dr. Sudbø,2 published in the issue of April 1, 2004, were derived from the same subjects followed through the same database, we have similar concerns. We have informed the director of Dr. Sudbø's institution, the Radiumhospitalet in Oslo, Norway, and await the results of his investigation.


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This editorial was published on January 20, 2006, at www.nejm.org.

  1. Sudbø J, Kildal W, Risberg B, et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-1278. [Free Full Text]
  2. Sudbø J, Lippman SM, Lee JJ, et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-1413. [Free Full Text]

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