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Correspondence
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Volume 354:764-765 February 16, 2006 Number 7
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Mycophenolate Mofetil or Intravenous Cyclophosphamide in Lupus Nephritis

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 by Ginzler, E. M.
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To the Editor: There are several reasons to be circumspect with regard to applying more widely the findings of the report by Ginzler et al. that compared cyclophosphamide and mycophenolate mofetil for the treatment of lupus nephritis (Nov. 25 issue).1 First, about 20 percent of the subjects had membranous nephropathy, a form of lupus nephritis for which the optimal treatment remains uncertain and for which treatment with cyclophosphamide has not been rigorously studied. Second, the rather narrow group of patients with adequately preserved renal function poses an obstacle to generalizing the study results to patients with lupus who have higher . . . [Full Text of this Article]




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