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Previous Volume 354:767-769 February 16, 2006 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The article by Berry et al. (Oct. 27 issue)¹ represents an impressive modeling exercise. However, the fact that all seven models of the effects of screening and adjuvant therapy on mortality from breast cancer yielded qualitatively similar results is not as remarkable as it might first appear. The reason is that the most likely source of bias is the combination of parameter estimates from different populations with different distributions of risk factors. Because all the models used the same data, any bias from the combination of different data sets would probably appear in all analyses. Another important . . . [Full Text of this Article]

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