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As the general population ages, we can expect the burden of neurodegenerative diseases to increase. Fortunately, recent research in the field puts us in an excellent position to ease this burden. Never before have we been better poised to develop treatments on the basis of the underlying causes of neurodegenerative diseases. These new treatments will promise not only relief from symptoms but also modification of the course of the disease. In the past dozen years, genes have been identified for the familial forms of amyotrophic lateral sclerosis (in 1993), Alzheimer's disease (in 1995), Parkinson's disease (in 1997), and hundreds of
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