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Previous Volume 354:841-848 February 23, 2006 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 66-year-old woman who is overweight reports bilateral knee pain of gradual onset during the past several months that increasingly has limited her activities. Last week, when walking down the stairs, she nearly fell when her knee gave way. She does not recall having injured her knee, and she has no morning stiffness and no pain in other joints. She has tried . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Diagnosis

Laboratory Tests

Treatment

            Nonsteroidal Antiinflammatory Drugs, Cyclooxygenase-2 Inhibitors, and Acetaminophen

            Injections of Hyaluronic Acid

            Glucosamine and Chondroitin Sulfate

            Other Pharmacologic Therapies

            Nonpharmacologic Treatment

            Correction of Malalignment

Guidelines

Summary and Recommendations

Source Information

From the Boston University School of Medicine, Boston.

Address reprint requests to Dr. Felson at A203, 80 E. Concord St., Boston University School of Medicine, Boston, MA 02118, or at jendez@bu.edu.

Related Letters:

Osteoarthritis of the Knee
Weinstein S. L., Jacobs J. J., Goldberg M. J., Koff R. S., Dart R. C., Felson D. T.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:2508-2509, Jun 8, 2006. Correspondence

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