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Volume 354:975-977 March 2, 2006 Number 9
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Acute Oxygen-Sensing Mechanisms

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by Weir, E. K.
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To the Editor: The review article by Weir et al. (Nov. 10 issue)1 on acute oxygen-sensing mechanisms omits one of the most important of the mechanisms: the angiotensin-converting–enzyme (ACE) molecule. ACE is enriched in the pulmonary circulation, where it appears to function not only as a mechanosensor2 but also as a reduction–oxidation (redox) sensor.3 A central role for ACE in ventilation–perfusion matching would explain its involvement in lung pathology.4,5 ACE inhibition or angiotensin II blockade may be effective for treating acute and chronic lung diseases, including the acute respiratory distress syndrome, high-altitude pulmonary edema, viral pneumonia, bronchiolitis obliterans, pulmonary fibrosis, . . . [Full Text of this Article]



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