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Volume 355:1070-1071 September 7, 2006 Number 10
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Hematopoietic Stem-Cell Transplantation

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by Copelan, E. A.
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To the Editor: Copelan (April 27 issue)1 provides a comprehensive review of hematopoietic stem-cell transplantation, including complications after transplantation. However, the review article does not describe a common complication that causes substantial excess mortality: renal injury.

During the first 2 weeks after transplantation, acute renal failure develops in up to 75% of patients receiving myeloablative regimens and approximately 33% of these patients require hemodialysis.2 The mortality rate among patients with acute renal failure is two to seven times that among patients without this complication.3

From 2 weeks to 3 months after transplantation, a spectrum of renal insults occurs secondary to . . . [Full Text of this Article]



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