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Volume 355:1071-1072 September 7, 2006 Number 10
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Molecular Profiling of a Tumor of Unknown Origin

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To the Editor: A 26-year-old woman had had abdominal pain since the beginning of her pregnancy. Endoscopy of the esophagus, stomach, and duodenum and abdominal ultrasonography showed only gastroesophageal reflux. Two months later, physical examination revealed a palpable left supraclavicular lymph node and hepatomegaly. Repeated abdominal ultrasonography showed multiple hepatic metastases.

The patient underwent an exploratory laparotomy during the 34th week of gestation, during which her baby was delivered by cesarean section; the infant was subsequently admitted to the neonatology unit. During the surgery, no primary tumor was identified. Hepatic biopsy showed a metastatic, well-differentiated mucinous adenocarcinoma. Mammography, breast ultrasonography, . . . [Full Text of this Article]


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