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Previous Volume 355:1154-1159 September 14, 2006 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.

A 62-year-old man was admitted to the intensive care unit (ICU) with severe community-acquired pneumonia. On the sixth hospital day, he remained intubated and was receiving broad-spectrum antibiotics for his pneumonia when an episode of hypotension occurred, requiring volume . . . [Full Text of this Article]

The Clinical Problem

Pathophysiology and Effect of Therapy

Clinical Evidence

Clinical Use

Adverse Effects

Areas of Uncertainty

Guidelines

Recommendations

Source Information

From the Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Related Letters:

Echinocandins for Candidemia
Garcia-Vidal C., Carratalà J., Bennett J. E.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:2791-2792, Dec 28, 2006. Correspondence

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• Garcia-Effron, G., Katiyar, S. K., Park, S., Edlind, T. D., Perlin, D. S. (2008). A Naturally Occurring Proline-to-Alanine Amino Acid Change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis Accounts for Reduced Echinocandin Susceptibility. Antimicrob. Agents Chemother. 52: 2305-2312 [Abstract] [Full Text]  
• Pfaller, M. A., Boyken, L., Hollis, R. J., Kroeger, J., Messer, S. A., Tendolkar, S., Diekema, D. J. (2008). In Vitro Susceptibility of Invasive Isolates of Candida spp. to Anidulafungin, Caspofungin, and Micafungin: Six Years of Global Surveillance. J. Clin. Microbiol. 46: 150-156 [Abstract] [Full Text]  
• Garcia-Vidal, C., Carratala, J., Bennett, J. E. (2006). Echinocandins for Candidemia. NEJM 355: 2791-2792 [Full Text]