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Previous Volume 355:1171-1172 September 14, 2006 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Vaccines that are composed of inactivated bacterial toxins work well for diseases such as diphtheria and tetanus, in which a single secreted toxin is the primary mediator of disease. Pathogens that rely on multiple secreted toxins, however, render vaccines impractical, partly owing to the fact that some toxins are directly injected into host cells and are therefore inaccessible to antibody. An alternative approach that is gaining momentum is to target the critical pathways required for toxin secretion.¹ Five distinct protein secretion pathways have been known to contribute to the virulence of bacterial pathogens. Recent studies by the Mekalanos group (Pukatzki . . . [Full Text of this Article]

Source Information

From the Department of Microbiology, University of Iowa, Iowa City.

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• Filloux, A., Hachani, A., Bleves, S. (2008). The bacterial type VI secretion machine: yet another player for protein transport across membranes. Microbiology 154: 1570-1583 [Abstract] [Full Text]  
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