FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 355:1253-1261 September 21, 2006 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text PowerPoint Slide Set Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

The deepening of our understanding of normal biology has made it clear that stem cells have a critical role not only in the generation of complex multicellular organisms, but also in the development of tumors. Recent findings support the concept that cells with the properties of stem cells are integral to the development and perpetuation of several forms of human cancer.^1,2,3 Eradication of the stem-cell compartment of a tumor also may be essential to achieve stable, long-lasting remission, and even a cure, of cancer.^4,5 Advances in our knowledge of the properties of stem cells have made specific targeting and eradication . . . [Full Text of this Article]

Background and Definitions

Cancer Stem Cells in the Hematopoietic System

Cancer Stem Cells in the Central Nervous System

Cancer Stem Cells in the Breast

Challenges for Therapy Targeted against Cancer Stem Cells

Summary

Source Information

From the James P. Wilmot Cancer Center (C.T.J., M.L.G.) and the Department of Biomedical Genetics (M.N.), University of Rochester School of Medicine, Rochester, NY.

Address reprint requests to Dr. Jordan at the University of Rochester School of Medicine, 601 Elmwood Ave., Box 703, Rochester, NY 14642, or at craig_jordan@urmc.rochester.edu.

Related Letters:

Cancer Stem Cells
Wion D., Berger F., Jordan C. T., Guzman M. L., Noble M.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:2703, Dec 21, 2006. Correspondence

This article has been cited by other articles:

• Kirkland, S. C., Ying, H. (2008). {alpha}2{beta}1 Integrin Regulates Lineage Commitment in Multipotent Human Colorectal Cancer Cells. J. Biol. Chem. 283: 27612-27619 [Abstract] [Full Text]  
• Chiba, T., Miyagi, S., Saraya, A., Aoki, R., Seki, A., Morita, Y., Yonemitsu, Y., Yokosuka, O., Taniguchi, H., Nakauchi, H., Iwama, A. (2008). The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma. Cancer Res. 68: 7742-7749 [Abstract] [Full Text]  
• Yi, J. M., Tsai, H.-C., Glockner, S. C., Lin, S., Ohm, J. E., Easwaran, H., James, C. D., Costello, J. F., Riggins, G., Eberhart, C. G., Laterra, J., Vescovi, A. L., Ahuja, N., Herman, J. G., Schuebel, K. E., Baylin, S. B. (2008). Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors. Cancer Res. 68: 8094-8103 [Abstract] [Full Text]  
• Vermeulen, L., Todaro, M., de Sousa Mello, F., Sprick, M. R., Kemper, K., Perez Alea, M., Richel, D. J., Stassi, G., Medema, J. P. (2008). Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc. Natl. Acad. Sci. USA 105: 13427-13432 [Abstract] [Full Text]  
• Tilly, J. L., Rueda, B. R. (2008). Stem Cell Contribution to Ovarian Development, Function, and Disease. Endocrinology 149: 4307-4311 [Abstract] [Full Text]  
• Bauerschmitz, G. J., Ranki, T., Kangasniemi, L., Ribacka, C., Eriksson, M., Porten, M., Herrmann, I., Ristimaki, A., Virkkunen, P., Tarkkanen, M., Hakkarainen, T., Kanerva, A., Rein, D., Pesonen, S., Hemminki, A. (2008). Tissue-Specific Promoters Active in CD44+CD24-/low Breast Cancer Cells. Cancer Res. 68: 5533-5539 [Abstract] [Full Text]  
• Colman, H., Aldape, K. (2008). Molecular Predictors in Glioblastoma: Toward Personalized Therapy. Arch Neurol 65: 877-883 [Abstract] [Full Text]  
• Chiou, S.-H., Yu, C.-C., Huang, C.-Y., Lin, S.-C., Liu, C.-J., Tsai, T.-H., Chou, S.-H., Chien, C.-S., Ku, H.-H., Lo, J.-F. (2008). Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma. Clin. Cancer Res. 14: 4085-4095 [Abstract] [Full Text]  
• Hassane, D. C., Guzman, M. L., Corbett, C., Li, X., Abboud, R., Young, F., Liesveld, J. L., Carroll, M., Jordan, C. T. (2008). Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. Blood 111: 5654-5662 [Abstract] [Full Text]  
• Eyler, C. E., Rich, J. N. (2008). Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis. JCO 26: 2839-2845 [Abstract] [Full Text]  
• Lichtenauer, U. D., Shapiro, I., Geiger, K., Quinkler, M., Fassnacht, M., Nitschke, R., Ruckauer, K.-D., Beuschlein, F. (2008). Side Population Does Not Define Stem Cell-Like Cancer Cells in the Adrenocortical Carcinoma Cell Line NCI h295R. Endocrinology 149: 1314-1322 [Abstract] [Full Text]  
• Lichtman, M. A. (2008). Battling the Hematological Malignancies: The 200 Years' War. The Oncologist 13: 126-138 [Abstract] [Full Text]  
• Zeppernick, F., Ahmadi, R., Campos, B., Dictus, C., Helmke, B. M., Becker, N., Lichter, P., Unterberg, A., Radlwimmer, B., Herold-Mende, C. C. (2008). Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients. Clin. Cancer Res. 14: 123-129 [Abstract] [Full Text]  
• Rich, J. N. (2007). Cancer Stem Cells in Radiation Resistance. Cancer Res. 67: 8980-8984 [Abstract] [Full Text]  
• Colombo, N., Parma, G., Zanagnolo, V., Insinga, A. (2007). Management of Ovarian Stromal Cell Tumors. JCO 25: 2944-2951 [Abstract] [Full Text]  
• Loebinger, M. R., Janes, S. M. (2007). Stem Cells for Lung Disease. Chest 132: 279-285 [Abstract] [Full Text]  
• Hosen, N., Park, C. Y., Tatsumi, N., Oji, Y., Sugiyama, H., Gramatzki, M., Krensky, A. M., Weissman, I. L. (2007). CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc. Natl. Acad. Sci. USA 104: 11008-11013 [Abstract] [Full Text]  
• Dalerba, P., Dylla, S. J., Park, I.-K., Liu, R., Wang, X., Cho, R. W., Hoey, T., Gurney, A., Huang, E. H., Simeone, D. M., Shelton, A. A., Parmiani, G., Castelli, C., Clarke, M. F. (2007). Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. USA 104: 10158-10163 [Abstract] [Full Text]  
• Francis, R., Richardson, C. (2007). Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements. Genes Dev. 21: 1064-1074 [Abstract] [Full Text]  
• Ramkissoon, S. H., Patel, P. S., Taborga, M., Rameshwar, P. (2007). Nuclear Factor-{kappa}B Is Central to the Expression of Truncated Neurokinin-1 Receptor in Breast Cancer: Implication for Breast Cancer Cell Quiescence within Bone Marrow Stroma. Cancer Res. 67: 1653-1659 [Abstract] [Full Text]  
• Wion, D., Berger, F., Jordan, C. T., Guzman, M. L., Noble, M. (2006). Cancer Stem Cells. NEJM 355: 2703-2703 [Full Text]