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Because we still do not know very much about the causes or the mechanisms of expression of the major psychiatric disorders, analogy may have substantial utility. Depression and Brain Dysfunction is a book of analogies devoted largely to examining mood disorders that occur in the context of neurologic diseases; its intent is to teach us about biologic mechanisms of idiopathic ("primary") depression.
I believe that there are four important questions about developmental neurobiology that must be answered in considering psychiatric conditions: How are we wired? How do learning, environment, experience, and powerful life events change brain function? How do we
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