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Volume 355:1390-1391 September 28, 2006 Number 13
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Homocysteine Lowering and Cognitive Performance

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by McMahon, J. A.
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To the Editor: McMahon et al. (June 29 issue)1 report that lowering plasma homocysteine concentrations by means of treatment with B vitamins did not improve the cognitive performance of healthy elderly volunteers with elevated homocysteine concentrations. Yet in the study population, there was little need to decrease homocysteine concentrations, no cognitive impairment to improve, and no association between elevated homocysteine concentrations and cognitive impairment to dissolve. What does it mean to improve an already quite normal cognitive performance and a mean score on the Mini–Mental State Examination of 29.2, given a possible score of 30? How can one define a . . . [Full Text of this Article]



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