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Volume 355:1497-1500 October 5, 2006 Number 14
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N-Acetylcysteine and Contrast-Induced Nephropathy

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 by Marenzi, G.
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To the Editor: The primary end point of the study by Marenzi et al. (June 29 issue)1 was the occurrence of contrast-medium–induced nephropathy, defined as an increase in the serum creatinine concentration of 25% or more from the baseline value within the 72-hour period after primary angioplasty. The reported incidence of contrast-medium–induced nephropathy varies widely among studies, since increases in the level of serum creatinine and the interval after the administration of contrast medium are not uniform among studies. In the Rapid Protocol for the Prevention of Contrast-Induced Renal Dysfunction (RAPPID) trial,2 contrast-medium–induced nephropathy was defined as a 25% increase . . . [Full Text of this Article]




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