In the June 3, 1948, issue of the Journal, Sydney Farber andhis colleagues reported that they had successfully used aminopterinto induce temporary remission in children with lymphoid leukemia.This exciting article suggested that what had been a uniformlyfatal disease might be amenable to treatment and, some daredto hope, cure. Then, in 1970, DeVita and his colleagues at theNational Cancer Institute showed that a combination of non–cross-reactivechemotherapeutic agents, the MOPP regimen (mechlorethamine,vincristine, procarbazine, and prednisone), could induce sustainedremission in advanced Hodgkin's disease. From such beginnings,an extraordinary success story unfolded, and today, more . . . [Full Text of this Article]
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Dr. Rosoff is an associate professor of pediatric hematology–oncology at Duke University School of Medicine and director of the Duke University Hospital Program in Clinical Ethics, Durham, NC.
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Survivors of Childhood Cancer
Goodwin T., Oosterhuis B. E., Hayes-Lattin B., the LIVESTRONG Young Adult Alliance , Sharma N., Melgar T., Brands C., Haupt R., Jankovic M., Veerman A. J.P., the International Berlin–Frankfurt–Münster Early and Late Toxicity Educational Committee , Oeffinger K. C., Sklar C. A., Robison L. L., Rosoff P. M.
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N Engl J Med 2007;
356:191-194, Jan 11, 2007.
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Goodwin, T., Oosterhuis, B. E., Hayes-Lattin, B., the LIVESTRONG Young Adult Alliance, , Sharma, N., Melgar, T., Brands, C., Haupt, R., Jankovic, M., Veerman, A. J.P., the International Berlin-Frankfurt-Munster Early a, , Oeffinger, K. C., Sklar, C. A., Robison, L. L., Rosoff, P. M.
(2007). Survivors of Childhood Cancer. NEJM
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