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Correspondence
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Volume 355:1935-1936 November 2, 2006 Number 18
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The Severe Gout of Emperor Charles V

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 by Ordi, J.
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To the Editor: Ordi et al. (Aug. 3 issue)1 confirm that the Holy Roman Emperor Charles V suffered from what physicians had long suspected was severe tophaceous gout.2 Lead poisoning may also have contributed to the decline and fall of this emperor.3 Saturnine gout results from exposure to lead through the addition of lead sugar (acetate) to wine to sweeten it and from the leaching of lead from glazes on amphora or from pewter drinking vessels.

Voracious consumption of wine (and lead) addled not only the Romans, but also the bibulous, podagrous English aristocrats of the 18th century,4 who were . . . [Full Text of this Article]




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