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Previous Volume 355:2003-2011 November 9, 2006 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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As an M.D.–Ph.D. student, I was fortunate to have worked in the laboratories of Earl Sutherland and Theodore Rall shortly after their discovery of cyclic adenosine monophosphate (AMP) in 1957 as a second messenger that mediates the glycogenolytic effects of epinephrine and glucagon.¹ My assignment was to examine the effects of catecholamines on cyclic AMP synthesis and determine whether these effects were mediated through the beta or alpha adrenergic receptor. This was actually a straightforward and simple student assignment.² I also found that choline esters such as acetylcholine, acting by transduction at the muscarinic receptor, inhibited adenylyl cyclase activity.² This . . . [Full Text of this Article]

Guanylyl Cyclase Activity

Endothelial Activity

Nitric Oxide Synthases

Activation of sGC

Steady-State Levels of Cyclic GMP

Cyclic GMP Signaling in Drug Development

Summary

Source Information

From the Brown Institute of Molecular Medicine, University of Texas Health Science Center, Houston.

Address reprint requests to Dr. Murad at the Health Science Center, 1825 Pressler St., Suite 500, University of Texas, Houston, TX 77030.

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