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An 89-year-old woman presented with a nonhealing ulcer on her right leg. She was taking 100 mg of minocycline orally twice a day as suppressive therapy for a corynebacterium infection that had occurred after orthopedic fixation of an intertrochanteric hip fracture 28 months earlier. Her physical examination was notable for a nonpalpable, nonpruritic hyperpigmentation of her legs (Panels A and B) and arms. Minocycline-induced hyperpigmentation was diagnosed, and the antimicrobial therapy was changed to cefadroxil. Several medications can cause hyperpigmentation, including minocycline, amiodarone, zidovudine, and bleomycin. Minocycline-induced hyperpigmentation can be severely disfiguring and is more likely to occur in certain . . . [Full Text of this Article] |
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