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Editorial
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Volume 355:2359-2361 November 30, 2006 Number 22
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Getting Smarter — The Toxicity of Undertreated HIV Infection
Judith S. Currier, M.D., and Lindsey R. Baden, M.D.

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by The Strategies for Management of Antiretroviral Therapy (SMART) Study Group
-PubMed Citation
Soon after the benefits of potent combination antiretroviral therapy were recognized in the late 1990s,1 clinicians understood that patients would need to be highly adherent to antiretroviral therapy and treated continuously with combination regimens. If this mark were not met, there was a real likelihood that a resistant virus would emerge. As experience with combination regimens expanded, data became available on long-term toxic effects, including dyslipidemia, changes in body fat, possibly increased cardiovascular risk, and hepatitis.2,3,4 Although infection with the human immunodeficiency virus (HIV) became a more manageable chronic disease, concerns about side effects led both patients and investigators to . . . [Full Text of this Article]


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From the University of California, Los Angeles (J.S.C.).


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