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Volume 355:2371-2373 November 30, 2006 Number 22
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Risks and Benefits of Celecoxib to Prevent Colorectal Adenomas

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To the Editor: In the article by Arber et al. (Aug. 31 issue)1 about the Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) trial, the percentage of patients with the combined end point of adjudicated serious cardiovascular events did not differ significantly between the celecoxib and placebo groups. Using data from Supplementary Appendix 2, we calculate that the rate ratio for "cardiac disorders" (including myocardial infarction) is 1.6 (95% confidence interval [CI], 0.9 to 2.8), whereas for "nervous system disorders" (including stroke), it is 0.7 (95% CI, 0.4 to 1.3). Similar results were reported by Bertagnolli et al.2 in the Supplementary . . . [Full Text of this Article]




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