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Previous Volume 355:2477-2480 December 7, 2006 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The twin epidemics of obesity and type 2 diabetes mellitus have spawned a public health crisis. In the United States, an estimated 1.5 million new cases of diabetes occur every year,¹ and the projected microvascular and cardiovascular complications² — already the greatest cause of blindness, kidney failure, and amputations in the Western world, and a substantial contributing factor in heart disease — are likely to become the major cause of preventable disease and premature death in this millennium.

The gravity of this epidemic is reflected by evidence-based efforts to stem it.^3,4 Moreover, in the United States, approval of five new . . . [Full Text of this Article]

Source Information

From the Diabetes Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.

This article was published at www.nejm.org on December 4, 2006.

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