Identification of new risk factors for specific diseases isan enduring theme in medical research. Advances in molecularbiology, genetics, and computational biology are acceleratingthe pace of this work. The research seeks to increase our understandingof the causes of diseases, but there is also hope that the recognitionof new risk factors will lead to improved methods for identifyingpersons who are in the early stages of, or at high risk for,the diseases of concern. Research has shown, however, that arisk factor must have a much stronger association with the diseaseoutcome than we ordinarily see . . . [Full Text of this Article]
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Dr. Ware is the dean for academic affairs and a professor of biostatistics at the Harvard School of Public Health, Boston, and a statistical consultant to the Journal.
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Biomarkers for Prediction of Cardiovascular Events
Musunuru K., Blumenthal R. S., Ridker P. M, Cook N. R., Becker D. M., Mora S., Goff D. C. Jr., Fletcher R. H., Fletcher S. W., Mints G., Shah N. R., Hauswald M., Wang T. J., Larson M. G., Vasan R. S., Ware J. H.
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N Engl J Med 2007;
356:1472-1475, Apr 5, 2007.
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