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Case Records of the Massachusetts General Hospital
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Volume 355:2678-2689 December 21, 2006 Number 25
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Case 39-2006 — A 24-Year-Old Woman with Systemic Lupus Erythematosus, Seizures, and Right Arm Weakness
Jang-Ho J. Cha, M.D., Ph.D., Karen Furie, M.D., Jonathan Kay, M.D., Rochelle P. Walensky, M.D., M.P.H., Mark E. Mullins, M.D., Ph.D., and E. Tessa Hedley-Whyte, M.D.

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Presentation of Case

Dr. Sherry Chou (Neurology): A 24-year-old woman was transferred to this hospital because of seizures and a lesion in the brain.

A diagnosis of systemic lupus erythematosus (SLE) had been made 6 years earlier, associated with polyarthritis, myalgia, malar rash, facial swelling, photosensitivity, pancytopenia, fevers, Raynaud's syndrome, pericardial and pleural effusion, membranous glomerulonephritis, and alopecia. She had been treated continuously with corticosteroids, with the addition of methotrexate, azathioprine, mycophenolate, leflunomide, and etanercept at various times, and dapsone prophylaxis. Her compliance with her medication regimen had been poor, and she had stopped taking dapsone 6 months earlier.

For several months, the . . . [Full Text of this Article]

Differential Diagnosis

Neurologic Localization of the Lesion

Radiologic Differential Diagnosis

Lupus Disease Activity

Neuropsychiatric Sle

Infection

Infections in Immunocompromised Patients

Lymphoma

Clinical Diagnosis

Pathological Discussion

Discussion of Management

Anatomical Diagnosis


Source Information

From the Departments of Neurology (J.-H.J.C., K.F.), Rheumatology (J.K.), Medicine and Infectious Disease (R.P.W.), Radiology (M.E.M.), and Pathology (E.T.H.-W.), Massachusetts General Hospital; and the Departments of Neurology (J.-H.J.C., K.F.), Medicine (J.K., R.P.W.), Radiology (M.E.M.), and Pathology (E.T.H.-W.), Harvard Medical School.


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