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Dr. Sherry Chou (Neurology): A 24-year-old woman was transferred to this hospital because of seizures and a lesion in the brain.
A diagnosis of systemic lupus erythematosus (SLE) had been made 6 years earlier, associated with polyarthritis, myalgia, malar rash, facial swelling, photosensitivity, pancytopenia, fevers, Raynaud's syndrome, pericardial and pleural effusion, membranous glomerulonephritis, and alopecia. She had been treated continuously with corticosteroids, with the addition of methotrexate, azathioprine, mycophenolate, leflunomide, and etanercept at various times, and dapsone prophylaxis. Her compliance with her medication regimen had been poor, and she had stopped taking dapsone 6 months earlier.
For several months, the
Differential Diagnosis
Neurologic Localization of the Lesion
Radiologic Differential Diagnosis
Lupus Disease Activity
Neuropsychiatric Sle
Infection
Infections in Immunocompromised Patients
Lymphoma
Clinical Diagnosis
Pathological Discussion
Discussion of Management
Anatomical Diagnosis
Source Information
From the Departments of Neurology (J.-H.J.C., K.F.), Rheumatology (J.K.), Medicine and Infectious Disease (R.P.W.), Radiology (M.E.M.), and Pathology (E.T.H.-W.), Massachusetts General Hospital; and the Departments of Neurology (J.-H.J.C., K.F.), Medicine (J.K., R.P.W.), Radiology (M.E.M.), and Pathology (E.T.H.-W.), Harvard Medical School.
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