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Correspondence
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Volume 355:2791-2792 December 28, 2006 Number 26
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Echinocandins for Candidemia

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 by Bennett, J. E.
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To the Editor: Bennett (Sept 14 issue)1 did not mention voriconazole as an option for the treatment of candidemia in adults without neutropenia. However, in December 2005, on the basis of a randomized, open-label, comparative, multicenter study involving 422 patients worldwide,2 the Food and Drug Administration approved the use of voriconazole for treating this infection. In this study, voriconazole was shown to be as effective as a regimen of amphotericin B followed by fluconazole. Treatment with voriconazole was better tolerated, and resulted in negative blood cultures as quickly as did treatment with amphotericin B and fluconazole.

Voriconazole has potent activity . . . [Full Text of this Article]




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