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Osteogenesis imperfecta is a heritable disorder caused by mutations in the gene for type I collagen. The Sillence classification of osteogenesis imperfecta (types I through IV) is based on clinical characteristics. Whole-body images of adults with osteogenesis imperfecta who were recruited for a clinical trial were acquired with the use of dual-energy x-ray absorptiometry. A wide spectrum of skeletal manifestations is apparent, from the mild abnormalities in the 38-year-old woman with type I osteogenesis imperfecta to the severe deformities in the 40-year-old man with type III disease. Scoliosis is present in most of the adults shown. One has orthopedic rods . . . [Full Text of this Article] |
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