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Volume 355:322-323 July 20, 2006 Number 3
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Hepatitis B Virus with Primary Resistance to Adefovir

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by Schildgen, O.
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To the Editor: Schildgen et al. (April 27 issue)1 describe the results of tenofovir treatment in three patients infected with adefovir-resistant variant hepatitis B virus (HBV) that had a valine at position 233 of the reverse-transcriptase domain instead of isoleucine (rtI233V). We recently published the results of two trials in which entecavir demonstrated superiority over lamivudine in patients with chronic hepatitis B that was positive for antibody against hepatitis B e antigen (HBeAg)2 and in patients with HBeAg-negative chronic hepatitis B.3

Four of the patients with HBeAg-positive chronic hepatitis B and four of those with HBeAg-negative chronic hepatitis B were . . . [Full Text of this Article]



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