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"When a plant goes to seed, its seeds are carried in all directions; but they can only live and grow if they fall on congenial soil." This analogy, in an article by the English surgeon Steven Paget published in the Lancet in 1889, was an attempt to explain the predilection of certain types of cancer to spread to bone and other tissues. More than a century later, the "seed and soil" theory is still being debated, and the discourse has expanded to include the biologic effect that the seed has on the soil after implantation. In an early chapter of
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