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Volume 355:422-423 July 27, 2006 Number 4
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Case 13-2006: A Man with a Bone Mass and Lesions in the Liver

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by Zhu, A. X.
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To the Editor: In the Case Records presented in the April 27 issue,1 which involved a patient with liver lesions and a bone mass in the right ulna, Hasserjian states that hepatocellular carcinoma "does not typically give rise to bony metastasis." In fact, bone metastases occur with regularity in hepatocellular carcinoma. Specifically, in a subgroup of 23 patients with metastatic hepatocellular carcinoma who received investigational thalidomide, bone lesions were present in 5 (22 percent) and were the third most common site of extrahepatic metastasis after lung and retroperitoneal lymph nodes.2 My colleagues and I noted bone metastases in 19 of . . . [Full Text of this Article]



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