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Previous Volume 355:516-520 August 3, 2006 Number 5 Next

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Holy Roman Emperor Charles V (who was also King Charles I of Spain) was one of the most powerful rulers of all time (Figure 1A). His 40-year reign (1516–1556) occurred during the transition from the Middle Ages to modern times. He was a global leader, governing territories in Europe, Africa, and Asia as well as the conquered territories of the Aztec Empire of Mexico and the Inca Kingdom of Peru. Given this reach, he was described as ruling an empire "in which the sun does not set." Despite this power, Charles V had to live within the limitations . . . [Full Text of this Article]

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From the Departments of Pathology (J.O., J.E., E.C., P.L.F.), Radiology (M.V.), and Biochemistry (E.M.), and the Center of International Health (P.L.A., J.Z.), Hospital Clínic d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona.

Related Letters:

The Severe Gout of Emperor Charles V
Couper R. T.L., Fernández P. L., Alonso P. L.
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N Engl J Med 2006; 355:1935-1936, Nov 2, 2006. Correspondence

This article has been cited by other articles:

• Couper, R. T.L., Fernandez, P. L., Alonso, P. L. (2006). The Severe Gout of Emperor Charles V. NEJM 355: 1935-1936 [Full Text]