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Correspondence
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Volume 355:528-529 August 3, 2006 Number 5
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COX-2 Inhibitors and Early Failure of Free Vascular Flaps

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To the Editor: We wish to report our clinical experience with the use of cyclooxygenase-2 (COX-2) inhibitors to control pain in patients treated with free vascular flaps after undergoing ablative surgery to resect an oral cancer. From January 1997 to February 2004, all patients who underwent ablative surgery at Helsinki University Central Hospital to resect a cancer, followed by surgical reconstruction of the maxillofacial skeleton with the use of a free vascular flap, received 2000 IU of dalteparin per kilogram of body weight twice daily and opioid medications, without the use of selective COX-2 inhibitors, as approved by the institutional . . . [Full Text of this Article]


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