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Correspondence
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Volume 355:624-626 August 10, 2006 Number 6
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Inhaled Corticosteroids and Children

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To the Editor: Guilbert and colleagues and Bisgaard and colleagues (May 11 issue)1,2 investigated the effect of inhaled corticosteroids in infants and preschool children with wheezing or an increased risk of asthma. The two studies, at best, found a marginal benefit in the inhaled-corticosteroid group, as compared with the placebo group. The treatment effect appeared to be somewhat stronger in the preschool cohort studied by Guilbert et al.

Guilbert et al. used propellant-driven metered-dose inhalers with fluticasone, and Bisgaard et al. used the same type of inhalers with budesonide, both delivered by means of a valved spacer. The particle size . . . [Full Text of this Article]


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