To the Editor: Guilbert and colleagues and Bisgaard and colleagues(May 11 issue)1,2 investigated the effect of inhaled corticosteroidsin infants and preschool children with wheezing or an increasedrisk of asthma. The two studies, at best, found a marginal benefitin the inhaled-corticosteroid group, as compared with the placebogroup. The treatment effect appeared to be somewhat strongerin the preschool cohort studied by Guilbert et al.
Guilbert et al. used propellant-driven metered-dose inhalerswith fluticasone, and Bisgaard et al. used the same type ofinhalers with budesonide, both delivered by means of a valvedspacer. The particle size . . . [Full Text of this Article]
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Ermers, M. J J, Rovers, M. M, van Woensel, J. B, Kimpen, J. L L, Bont, L. J, on behalf of the RSV Corticosteroid Study Group,
(2009). The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial. BMJ
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