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Correspondence
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Volume 355:740-741 August 17, 2006 Number 7
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Infliximab for Rheumatoid Arthritis in a Patient with Tuberculosis

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To the Editor: Tumor necrosis factor {alpha} antagonists have been shown to be effective agents in the treatment of rheumatoid arthritis; however, they have also been shown to increase the risk of the reactivation of tuberculosis in patients with latent infection1,2 and may render the tuberculosis refractory to drug therapy.3,4 Decisions regarding the treatment of patients with refractory rheumatoid arthritis in the setting of active tuberculosis remain difficult.

A 64-year-old woman with a 10-year history of rheumatoid arthritis (functional class III and radiologic stage 3, according to Steinbrocker's criteria) had begun treatment with infliximab at a dose of 3 mg per . . . [Full Text of this Article]


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