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Previous Volume 355:953-954 August 31, 2006 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The 1989 Nobel Prize in Chemistry was awarded to Sidney Altman and Thomas Cech for the discovery that RNA is not only a molecule of heredity, it is also a biocatalyst. The Royal Swedish Academy of Sciences offered a prescient comment when it announced the award¹: the "future use of gene shears will require that we learn more about the molecular mechanisms . . . of RNA." The discovery of RNA interference (RNAi),² an evolutionarily conserved mechanism that silences gene expression, underscores this point. Perhaps even more exciting than its discovery is the specter of harnessing this robust and specific gene-silencing . . . [Full Text of this Article]

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From the Division of Nephrology, St. Michael's Hospital and the University of Toronto, Toronto.

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