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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the authors' clinical recommendations.
A 58-year-old man has chest pain at 9:30 a.m.; 3 hours later, he calls for an ambulance. Paramedics arrive, provide standard treatment, and transport him to the nearest emergency department. On his arrival at a small hospital at 1
The Clinical Problem
Pathophysiology and Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Department of Internal Medicine (Cardiology Division), University of Virginia School of Medicine, Charlottesville (E.C.K.); and the Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas (L.D.H.).
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Brown D. C., Szabo S., Oikonomopoulos T., Hoffmeister H. M., Kashyap A. S., Kashyap S., Anand K. P., Keeley E. C., Hillis L. D.
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N Engl J Med 2007;
356:1588-1590, Apr 12, 2007.
Correspondence
This article has been cited by other articles:
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