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Previous Volume 356:92-94 January 4, 2007 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We wish to reframe the discussion regarding the neurodevelopmental manifestations of the tuberous sclerosis complex (TSC) in the overview of TSC by Crino et al. (Sept. 28 issue).¹ First, the authors state, "Epilepsy may be the most prevalent and challenging clinical manifestation of TSC." However, patients and caregivers have reported that cognitive and behavioral difficulties are the greatest challenge, over and above epilepsy,² and they continue to do so. Almost everyone with TSC, even in the absence of epilepsy, has clinically significant cognitive or behavioral problems.³

Second, the authors state that the neurobehavioral abnormalities "appear to be . . . [Full Text of this Article]

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