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Previous Volume 356:1030-1039 March 8, 2007 Number 10 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Supplementary Material Perspective by Maisel, W. H. Perspective by Farb, A. Editorial by Curfman, G. D. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Maisel, W. H. Related Article by Farb, A. PubMed Citation

ABSTRACT

Background The long-term effects of treatment with sirolimus-eluting stents, as compared with bare-metal stents, have not been established.

Methods We performed an analysis of individual data on 4958 patients enrolled in 14 randomized trials comparing sirolimus-eluting stents with bare-metal stents (mean follow-up interval, 12.1 to 58.9 months). The primary end point was death from any cause. Other outcomes were stent thrombosis, the composite end point of death or myocardial infarction, and the composite of death, myocardial infarction, or reintervention.

Results The overall risk of death (hazard ratio, 1.03; 95% confidence interval [CI], 0.80 to 1.30) and the combined risk of death or myocardial infarction (hazard ratio, 0.97; 95% CI, 0.81 to 1.16) were not significantly different for patients receiving sirolimus-eluting stents versus bare-metal stents. There was a significant reduction in the combined risk of death, myocardial infarction, or reintervention (hazard ratio, 0.43; 95% CI, 0.34 to 0.54) associated with the use of sirolimus-eluting stents. There was no significant difference in the overall risk of stent thrombosis with sirolimus-eluting stents versus bare-metal stents (hazard ratio, 1.09; 95% CI, 0.64 to 1.86). However, there was evidence of a slight increase in the risk of stent thrombosis associated with sirolimus-eluting stents after the first year.

Conclusions The use of sirolimus-eluting stents does not have a significant effect on overall long-term survival and survival free of myocardial infarction, as compared with bare-metal stents. There is a sustained reduction in the need for reintervention after the use of sirolimus-eluting stents. The risk of stent thrombosis is at least as great as that seen with bare-metal stents.

Source Information

From Deutsches Herzzentrum, Technische Universität, Munich, Germany (A.K., J.M., J.P., M. Seyfarth, A.S.); University of Basel, Basel, Switzerland (C.K., M.E.P.); University of Ferrara, Ferrara, Italy (M.V.); Rigshospitalet, Copenhagen (H.K.); San Camillo Hospital, Rome (M.M.); Cardiovascular Institute, Hospital de la Santa Creu i Sant Pau, Barcelona (M. Sabaté); St. Antonius Hospital, Nieuwegein, the Netherlands (M.J.S.); and Preventicum–Klinik für Diagnostik, Essen, Germany (D.B.).

This article (10.1056/NEJMoa067484) was published at www.nejm.org on February 12, 2007.

Address reprint requests to Dr. Kastrati at Deutsches Herzzentrum, Lazarettstr. 36, 80636 Munich, Germany, or at kastrati{at}dhm.mhn.de.

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• Booth, J., Clayton, T., Pepper, J., Nugara, F., Flather, M., Sigwart, U., Stables, R. H., on Behalf of the SoS Investigators, (2008). Randomized, Controlled Trial of Coronary Artery Bypass Surgery Versus Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease: Six-Year Follow-Up From the Stent or Surgery Trial (SoS). Circulation 118: 381-388 [Abstract] [Full Text]  
• Coylewright, M., Blumenthal, R. S., Post, W. (2008). Placing COURAGE in Context: Review of the Recent Literature on Managing Stable Coronary Artery Disease. Mayo Clin Proc. 83: 799-805 [Abstract] [Full Text]  
• Malenka, D. J., Kaplan, A. V., Lucas, F. L., Sharp, S. M., Skinner, J. S. (2008). Outcomes Following Coronary Stenting in the Era of Bare-Metal vs the Era of Drug-Eluting Stents. JAMA 299: 2868-2876 [Abstract] [Full Text]  
• Austin, D., Oldroyd, K. G., McConnachie, A., Slack, R., Eteiba, H., Flapan, A. D., Jennings, K. P., Northcote, R. J., Pell, A. C. H., Starkey, I. R., Pell, J. P. (2008). Hospital and operator variations in drug-eluting stent use: a multi-level analysis of 5967 consecutive patients in Scotland. J Public Health (Oxf) 30: 186-193 [Abstract] [Full Text]  
• Li, J., Jabara, R., Pendyala, L., Otsuka, Y., Shinke, T., Hou, D., Robinson, K., Chronos, N. (2008). Abnormal Vasomotor Function of Porcine Coronary Arteries Distal to Sirolimus-Eluting Stents. J Am Coll Cardiol Intv 1: 279-285 [Abstract] [Full Text]  
• Becker, R. C., Meade, T. W., Berger, P. B., Ezekowitz, M., O'Connor, C. M., Vorchheimer, D. A., Guyatt, G. H., Mark, D. B., Harrington, R. A. (2008). The Primary and Secondary Prevention of Coronary Artery Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 776S-814S [Abstract] [Full Text]  
• Kelbaek, H., Klovgaard, L., Helqvist, S., Lassen, J. F., Krusell, L. R., Engstrom, T., Botker, H. E., Jorgensen, E., Saunamaki, K., Aljabbari, S., Thayssen, P., Galloe, A., Jensen, G. V.H., Thuesen, L. (2008). Long-Term Outcome in Patients Treated With Sirolimus-Eluting Stents in Complex Coronary Artery Lesions: 3-Year Results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) Trial. J Am Coll Cardiol 51: 2011-2016 [Abstract] [Full Text]  
• Groeneveld, P. W., Matta, M. A., Greenhut, A. P., Yang, F. (2008). Drug-Eluting Compared With Bare-Metal Coronary Stents Among Elderly Patients. J Am Coll Cardiol 51: 2017-2024 [Abstract] [Full Text]  
• Mark, D. B. (2008). Interpreting the Music of Drug-Eluting Stents: Halcyon Song or Albatross Dirge?. J Am Coll Cardiol 51: 1854-1856 [Full Text]  
• Bhatt, S. H, Hauser, T. H (2008). Very Late Stent Thrombosis After Dual Antiplatelet Therapy Discontinuation in a Patient with a History of Acute Stent Thrombosis. The Annals of Pharmacotherapy 42: 708-712 [Abstract] [Full Text]  
• Hannan, E. L., Racz, M., Holmes, D. R., Walford, G., Sharma, S., Katz, S., Jones, R. H., King, S. B. III (2008). Comparison of Coronary Artery Stenting Outcomes in the Eras Before and After the Introduction of Drug-Eluting Stents. Circulation 117: 2071-2078 [Abstract] [Full Text]  
• Zellweger, M. J., Kaiser, C., Brunner-La Rocca, H. P., Buser, P. T., Osswald, S., Weiss, P., Mueller-Brand, J., Pfisterer, M. E., for the BASKET Investigators, (2008). Value and Limitations of Target-Vessel Ischemia in Predicting Late Clinical Events After Drug-Eluting Stent Implantation. JNM 49: 550-556 [Abstract] [Full Text]  
• Taggart, D. P., Kaul, S., Boden, W. E., Ferguson, T. B. Jr, Guyton, R. A., Mack, M. J., Sergeant, P. T., Shemin, R. J., Smith, P. K., Yusuf, S. (2008). Revascularization for unprotected left main stem coronary artery stenosis stenting or surgery.. J Am Coll Cardiol 51: 885-892 [Abstract] [Full Text]  
• Kirtane, A. J., Ellis, S. G., Dawkins, K. D., Colombo, A., Grube, E., Popma, J. J., Fahy, M., Leon, M. B., Moses, J. W., Mehran, R., Stone, G. W. (2008). Paclitaxel-Eluting Coronary Stents in Patients With Diabetes Mellitus Pooled Analysis From 5 Randomized Trials.. J Am Coll Cardiol 51: 708-715 [Abstract] [Full Text]  
• Ortolani, P., Balducelli, M., Marzaroli, P., Piovaccari, G., Menozzi, A., Guiducci, V., Sangiorgio, P., Tarantino, F., Geraci, G., Castriota, F., Tondi, S., Saia, F., Cooke, R. M.T., Guastaroba, P., Grilli, R., Marzocchi, A., Maresta, A. (2008). Two-Year Clinical Outcomes With Drug-Eluting Stents for Diabetic Patients With De Novo Coronary Lesions: Results From a Real-World Multicenter Registry. Circulation 117: 923-930 [Abstract] [Full Text]  
• Jeremias, A., Kirtane, A. (2008). Balancing Efficacy and Safety of Drug-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention. ANN INTERN MED 148: 234-238 [Abstract] [Full Text]  
• Saia, F., Marzocchi, A., Branzi, A. (2008). Review: The safety of drug-eluting stents. Ther Adv Cardiovasc Dis 2: 43-52 [Abstract]  
• Austin, D., Pell, J. P, Oldroyd, K. G (2008). Drug-eluting stents: do the risks really outweigh the benefits?. Heart 94: 127-128 [Full Text]  
• Melikian, N, Wijns, W (2008). Drug-eluting stents: a critique. Heart 94: 145-152 [Abstract] [Full Text]  
• Romagnoli, E., Sangiorgi, G. M., Cosgrave, J., Guillet, E., Colombo, A. (2008). Drug-eluting stenting the case for post-dilation.. J Am Coll Cardiol Intv 1: 22-31 [Abstract] [Full Text]  
• Holmes, D. R. Jr, Gersh, B. J., Whitlow, P., King, S. B. III, Dove, J. T. (2008). Percutaneous coronary intervention for chronic stable angina a reassessment.. J Am Coll Cardiol Intv 1: 34-43 [Abstract] [Full Text]  
• American College of Cardiology/American Heart Asso, , 2007 Writing Group to Review New Evidence and Upda, , King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention. J Am Coll Cardiol 51: 172-209 [Full Text]  
• King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O., 2005 WRITING COMMITTEE MEMBERS, , Smith, S. C. Jr, Feldman, T. E., Hirshfeld, J. W. Jr, Jacobs, A. K., Kern, M. J., King, S. B. III, Morrison, D. A., O'Neill, W. W., Schaff, H. V., Whitlow, P. L., Williams, D. O., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Buller, C. E., Creager, M. A., Ettinger, S. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence and Update the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention, Writing on Behalf of the 2005 Writing Committee. Circulation 117: 261-295 [Full Text]  
• Gitt, A. K., Betriu, A. (2008). Antiplatelet therapy in acute coronary syndromes. Eur Heart J Suppl 10: A4-A12 [Abstract] [Full Text]  
• Abbott, J. D., Voss, M. R., Nakamura, M., Cohen, H. A., Selzer, F., Kip, K. E., Vlachos, H. A., Wilensky, R. L., Williams, D. O. (2007). Unrestricted Use of Drug-Eluting Stents Compared With Bare-Metal Stents in Routine Clinical Practice: Findings From the National Heart, Lung, and Blood Institute Dynamic Registry. J Am Coll Cardiol 50: 2029-2036 [Abstract] [Full Text]  
• Buttner, H. J., Neumann, F.-J. (2007). Peeling-Off Labels: Mounting Evidence for Benefit of Drug-Eluting Stents With Off-Label Use. J Am Coll Cardiol 50: 2037-2038 [Full Text]  
• Doyle, B., Rihal, C. S., O'Sullivan, C. J., Lennon, R. J., Wiste, H. J., Bell, M., Bresnahan, J., Holmes, D. R. Jr (2007). Outcomes of Stent Thrombosis and Restenosis During Extended Follow-Up of Patients Treated With Bare-Metal Coronary Stents. Circulation 116: 2391-2398 [Abstract] [Full Text]  
• Kastrati, A., Dibra, A., Spaulding, C., Laarman, G. J., Menichelli, M., Valgimigli, M., Di Lorenzo, E., Kaiser, C., Tierala, I., Mehilli, J., Seyfarth, M., Varenne, O., Dirksen, M. T., Percoco, G., Varricchio, A., Pittl, U., Syvanne, M., Suttorp, M. J., Violini, R., Schomig, A. (2007). Meta-analysis of randomized trials on drug-eluting stents vs. bare-metal stents in patients with acute myocardial infarction. Eur Heart J 28: 2706-2713 [Abstract] [Full Text]  
• Lamas, G. A, Hochman, J. S (2007). Where does the Occluded Artery Trial leave the late open artery hypothesis?. Heart 93: 1319-1321 [Abstract] [Full Text]  
• Fleisher, L. A., Beckman, J. A., Brown, K. A., Calkins, H., Chaikof, E. L., Fleischmann, K. E., Freeman, W. K., Froehlich, J. B., Kasper, E. K., Kersten, J. R., Riegel, B., Robb, J. F., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Buller, C. E., Creager, M. A., Ettinger, S. M., Faxon, D. P., Fuster, V., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2007). ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol 50: e159-e242 [Full Text]