Safety and Efficacy of Sirolimus- and Paclitaxel-Eluting Coronary Stents

doi:10.1056/NEJMoa067193

Volume 356:998-1008		March 8, 2007		Number 10

Safety and Efficacy of Sirolimus- and Paclitaxel-Eluting Coronary Stents

Gregg W. Stone, M.D., Jeffrey W. Moses, M.D., Stephen G. Ellis, M.D., Joachim Schofer, M.D., Keith D. Dawkins, M.D., Marie-Claude Morice, M.D., Antonio Colombo, M.D., Erick Schampaert, M.D., Eberhard Grube, M.D., Ajay J. Kirtane, M.D., Donald E. Cutlip, M.D., Martin Fahy, M.Sc., Stuart J. Pocock, Ph.D., Roxana Mehran, M.D., and Martin B. Leon, M.D.

Full Text

PDF

PDA Full Text

PowerPoint Slide Set

CME Exam

Supplementary Material

Perspective
by Maisel, W. H.
Perspective
by Farb, A.

Editorial
by Curfman, G. D.

Add to Personal Archive

Add to Citation Manager

Notify a Friend

E-mail When Cited

E-mail When Letters Appear

PubMed Citation

ABSTRACT

Background The safety of drug-eluting stents has been calledinto question by recent reports of increased stent thrombosis,myocardial infarction, and death. Such studies have been inconclusivebecause of their insufficient size, the use of historical controls,a limited duration of follow-up, and a lack of access to originalsource data.

Methods We performed a pooled analysis of data from four double-blindtrials in which 1748 patients were randomly assigned to receiveeither sirolimus-eluting stents or bare-metal stents and fivedouble-blind trials in which 3513 patients were randomly assignedto receive either paclitaxel-eluting stents or bare-metal stents;we then analyzed the major clinical end points of the trials.

Results The 4-year rates of stent thrombosis were 1.2% in thesirolimus-stent group versus 0.6% in the bare-metal–stentgroup (P=0.20) and 1.3% in the paclitaxel-stent group versus0.9% in the bare-metal–stent group (P=0.30). However,after 1 year, there were five episodes of stent thrombosis inpatients with sirolimus-eluting stents versus none in patientswith bare-metal stents (P=0.025) and nine episodes in patientswith paclitaxel-eluting stents versus two in patients with bare-metalstents (P=0.028). The 4-year rates of target-lesion revascularizationwere markedly reduced in both the sirolimus-stent group andthe paclitaxel-stent group, as compared with the bare-metal–stentgroups. The rates of death or myocardial infarction did notdiffer significantly between the groups with drug-eluting stentsand those with bare-metal stents.

Conclusions Stent thrombosis after 1 year was more common withboth sirolimus-eluting stents and paclitaxel-eluting stentsthan with bare-metal stents. Both drug-eluting stents were associatedwith a marked reduction in target-lesion revascularization.There were no significant differences in the cumulative ratesof death or myocardial infarction at 4 years.

Source Information

From Columbia University Medical Center and the Cardiovascular Research Foundation, New York (G.W.S., J.W.M., A.J.K., M.F., R.M., M.B.L.); Cleveland Clinic, Cleveland (S.G.E.); Hamburg University Cardiovascular Center, Hamburg, Germany (J.S.); Southampton University Hospital, Southampton, United Kingdom (K.D.D.); Institut Cardiovasculaire Paris Sud, Massy, France (M.-C.M.); San Raffaele Hospital, Milan (A.C.); Hôpital du Sacre-Coeur de Montréal, Montreal (E.S.); Heart Center Siegburg, Siegburg, Germany (E.G.); Harvard Clinical Research Institute, Boston (D.E.C.); and the London School of Hygiene and Tropical Medicine, London (S.J.P.).

This article (10.1056/NEJMoa067193) was published at www.nejm.org on February 12, 2007.

Address reprint requests to Dr. Stone at Columbia University Medical Center, Cardiovascular Research Foundation, 111 E. 59th St., 11th Fl., New York, NY 10022, or at gs2184{at}columbia.edu.

Full Text of this Article

This article has been cited by other articles:

Pfisterer, M. E (2008). Commentary on drug-eluting stents: to use or not to use--that is the question!. Heart 94: 1648-1650 [Full Text]
Authors/writing members, , Daemen, J., Simoons, M. L., Wijns, W., Bagust, A., Bos, G., Bowen, J. M., Braunwald, E., Camenzind, E., Chevalier, B., DiMario, C., Fajadet, J., Gitt, A., Guagliumi, G., Hillege, H. L., James, S., Juni, P., Kastrati, A., Kloth, S., Kristensen, S. D., Krucoff, M., Legrand, V., Pfisterer, M., Rothman, M., Serruys, P. W., Silber, S., Steg, P. G., Tariah, I., Wallentin, L., Windecker, S. W., Participants in the Forum, , Aimonetti, A., Allocco, D., Baczynska, A., Bagust, A., Berenger, M., Bos, G., Boam, A., Bowen, J.M., Braunwald, E., Calle, J.P., Camenzind, E., Campo, G., Carlier, S., Chevalier, B., Daemen, J., de Schepper, J., Di Bisceglie, G., DiMario, C., Dobbels, H., Fajadet, J., Farb, A., Ghislain, J.C., Gitt, A., Guagliumi, G., Hellbardt, S., Hillege, H.L., ten Hoedt, R., Isaia, C., James, S., de Jong, P., Juni, P., Kastrati, A., Klasen, E., Kloth, S., Kristensen, S.D., Krucoff, M., Legrand, V., Lekehal, M., LeNarz, L., Ni Mhullain, F., Nagai, H., Patteet, A., Paunovic, D., Pfisterer, M., Potgieter, A., Purdy, I., Raveau-Landon, C., Rothman, M., Serruys, P.W., Silber, S., Simoons, M.L., Steg, P.G., Tariah, I., Ternstrom, S., Van Wuytswinkel, J., Waliszewski, M., Wallentin, L., Wijns, W., Windecker, S.W. (2008). Meeting Report * ESC Forum on Drug Eluting Stents * European Heart House, Nice, 27-28 September 2007. Eur Heart J 0: ehn510v1-10 [Full Text]
Pfisterer, M., Brunner-La Rocca, H. P., Rickenbacher, P., Hunziker, P., Mueller, C., Nietlispach, F., Leibundgut, G., Bader, F., Kaiser, C., for the BASKET Investigators, (2008). Long-term benefit-risk balance of drug-eluting vs. bare-metal stents in daily practice: does stent diameter matter? Three-year follow-up of BASKET. Eur Heart J 0: ehn516v1-9 [Abstract] [Full Text]
Alfonso, F., Perez-Vizcayno, M.-J., Hernandez, R., Bethencourt, A., Marti, V., Lopez-Minguez, J. R., Angel, J., Iniguez, A., Moris, C., Cequier, A., Sabate, M., Escaned, J., Jimenez-Quevedo, P., Banuelos, C., Suarez, A., Macaya, C., for the RIBS-II Investigators, (2008). Long-Term Clinical Benefit of Sirolimus-Eluting Stents in Patients With In-Stent Restenosis: Results of the RIBS-II (Restenosis Intra-stent: Balloon angioplasty vs. elective sirolimus-eluting Stenting) Study. J Am Coll Cardiol 52: 1621-1627 [Abstract] [Full Text]
Go, A. S., Magid, D. J., Wells, B., Sung, S. H., Cassidy-Bushrow, A. E., Greenlee, R. T., Langer, R. D., Lieu, T. A., Margolis, K. L., Masoudi, F. A., McNeal, C. J., Murata, G. H., Newton, K. M., Novotny, R., Reynolds, K., Roblin, D. W., Smith, D. H., Vupputuri, S., White, R. E., Olson, J., Rumsfeld, J. S., Gurwitz, J. H. (2008). The Cardiovascular Research Network: A New Paradigm for Cardiovascular Quality and Outcomes Research. Circ Cardiovasc Qual Outcomes 1: 138-147 [Abstract] [Full Text]
Mauri, L., Silbaugh, T. S., Wolf, R. E., Zelevinsky, K., Lovett, A., Zhou, Z., Resnic, F. S., Normand, S.-L. T. (2008). Long-Term Clinical Outcomes After Drug-Eluting and Bare-Metal Stenting in Massachusetts. Circulation 118: 1817-1827 [Abstract] [Full Text]
Lin, G. A., Dudley, R. A., Lucas, F. L., Malenka, D. J., Vittinghoff, E., Redberg, R. F. (2008). Frequency of Stress Testing to Document Ischemia Prior to Elective Percutaneous Coronary Intervention. JAMA 300: 1765-1773 [Abstract] [Full Text]
Byrne, J. G., Leacche, M., Vaughan, D. E., Zhao, D. X. (2008). Hybrid Cardiovascular Procedures. J Am Coll Cardiol Intv 1: 459-468 [Abstract] [Full Text]
Park, D.-W., Yun, S.-C., Lee, S.-W., Kim, Y.-H., Lee, C. W., Hong, M.-K., Cheong, S.-S., Kim, J.-J., Park, S.-W., Park, S.-J. (2008). Stent Thrombosis, Clinical Events, and Influence of Prolonged Clopidogrel Use After Placement of Drug-Eluting Stent: Data From an Observational Cohort Study of Drug-Eluting Versus Bare-Metal Stents. J Am Coll Cardiol Intv 1: 494-503 [Abstract] [Full Text]
Costa, J. R. Jr, Abizaid, A., Costa, R., Feres, F., Tanajura, L. F., Abizaid, A., Mattos, L. A., Staico, R., Siqueira, D., Sousa, A. G.M.R., Bonan, R., Sousa, J. E. (2008). Preliminary Results of the Hydroxyapatite Nonpolymer-Based Sirolimus-Eluting Stent for the Treatment of Single De Novo Coronary Lesions: A First-in-Human Analysis of a Third-Generation Drug-Eluting Stent System. J Am Coll Cardiol Intv 1: 545-551 [Abstract] [Full Text]
Kukreja, N., Onuma, Y., Garcia-Garcia, H., Daemen, J., van Domburg, R., Serruys, P. W. (2008). Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction: Long-Term Outcome After Bare Metal and Drug-Eluting Stent Implantation. Circ Cardiovasc Intervent 1: 103-110 [Abstract] [Full Text]
Wenaweser, P., Daemen, J., Zwahlen, M., van Domburg, R., Juni, P., Vaina, S., Hellige, G., Tsuchida, K., Morger, C., Boersma, E., Kukreja, N., Meier, B., Serruys, P. W., Windecker, S. (2008). Incidence and Correlates of Drug-Eluting Stent Thrombosis in Routine Clinical Practice: 4-Year Results From a Large 2-Institutional Cohort Study. J Am Coll Cardiol 52: 1134-1140 [Abstract] [Full Text]
Daemen, J., Boersma, E., Flather, M., Booth, J., Stables, R., Rodriguez, A., Rodriguez-Granillo, G., Hueb, W. A., Lemos, P. A., Serruys, P. W. (2008). Long-Term Safety and Efficacy of Percutaneous Coronary Intervention With Stenting and Coronary Artery Bypass Surgery for Multivessel Coronary Artery Disease: A Meta-Analysis With 5-Year Patient-Level Data From the ARTS, ERACI-II, MASS-II, and SoS Trials. Circulation 118: 1146-1154 [Abstract] [Full Text]
Nakazawa, G., Finn, A. V., Joner, M., Ladich, E., Kutys, R., Mont, E. K., Gold, H. K., Burke, A. P., Kolodgie, F. D., Virmani, R. (2008). Delayed Arterial Healing and Increased Late Stent Thrombosis at Culprit Sites After Drug-Eluting Stent Placement for Acute Myocardial Infarction Patients: An Autopsy Study. Circulation 118: 1138-1145 [Abstract] [Full Text]
Kirtane, A. J., Cohen, D. J. (2008). When Is Better Not Good Enough?: Insights From the COURAGE Economic Study. Circ Cardiovasc Qual Outcomes 1: 4-6 [Full Text]
Chieffo, A., Park, S.-J., Meliga, E., Sheiban, I., Lee, M. S., Latib, A., Kim, Y.-H., Valgimigli, M., Sillano, D., Magni, V., Biondi-Zoccai, G., Montorfano, M., Airoldi, F., Rogacka, R., Carlino, M., Michev, I., Lee, C.-W., Hong, M.-K., Park, S.-W., Moretti, C., Bonizzoni, E., Sangiorgi, G. M., Tobis, J., Serruys, P. W., Colombo, A. (2008). Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry. Eur Heart J 29: 2108-2115 [Abstract] [Full Text]
Hamdalla, H., Moliterno, D. J. (2008). Late drug-eluting stent thrombosis in unprotected left main coronary artery lesions--sometimes possible, but rarely definite or probable. Eur Heart J 29: 2064-2066 [Full Text]
Anstrom, K. J., Kong, D. F., Shaw, L. K., Califf, R. M., Kramer, J. M., Peterson, E. D., Rao, S. V., Matchar, D. B., Mark, D. B., Harrington, R. A., Eisenstein, E. L. (2008). Long-term Clinical Outcomes Following Coronary Stenting. Arch Intern Med 168: 1647-1655 [Abstract] [Full Text]
Abbott, J. D. (2008). Revealing the Silver and Red Lining in Drug-Eluting Stents With Angioscopy. Circ Cardiovasc Intervent 1: 7-9 [Full Text]
Shinke, T., Li, J., Chen, J. P., Pendyala, L., Goodchild, T., Jabara, R., Geva, S., Ueno, T., Chronos, N., Robinson, K., Hou, D. (2008). High Incidence of Intramural Thrombus After Overlapping Paclitaxel-Eluting Stent Implantation: Angioscopic and Histopathologic Analysis in Porcine Coronary Arteries. Circ Cardiovasc Intervent 1: 28-35 [Abstract] [Full Text]
Austin, D., Oldroyd, K. G., McConnachie, A., Slack, R., Eteiba, H., Flapan, A. D., Jennings, K. P., Northcote, R. J., Pell, A. C.H., Starkey, I. R., Pell, J. P. (2008). Drug-Eluting Stents Versus Bare-Metal Stents for Off-Label Indications: A Propensity Score-Matched Outcome Study. Circ Cardiovasc Intervent 1: 45-52 [Abstract] [Full Text]
Brodie, B. R., Stuckey, T., Downey, W., Humphrey, A., Bradshaw, B., Metzger, C., Hermiller, J., Krainin, F., Juk, S., Cheek, B., Duffy, P., Smith, H., Edmunds, J., Varanasi, J., Simonton, C. A., STENT (Strategic Transcatheter Evaluation of New T, (2008). Outcomes and Complications With Off-Label Use of Drug-Eluting Stents: Results From the STENT (Strategic Transcatheter Evaluation of New Therapies) Group. J Am Coll Cardiol Intv 1: 405-414 [Abstract] [Full Text]
Newsome, L. T., Kutcher, M. A., Royster, R. L. (2008). Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention. Anesth. Analg. 107: 552-569 [Abstract] [Full Text]
Stone, G. W. (2008). Angioplasty Strategies in ST-Segment-Elevation Myocardial Infarction: Part I: Primary Percutaneous Coronary Intervention. Circulation 118: 538-551 [Full Text]
Booth, J., Clayton, T., Pepper, J., Nugara, F., Flather, M., Sigwart, U., Stables, R. H., on Behalf of the SoS Investigators, (2008). Randomized, Controlled Trial of Coronary Artery Bypass Surgery Versus Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease: Six-Year Follow-Up From the Stent or Surgery Trial (SoS). Circulation 118: 381-388 [Abstract] [Full Text]
Ellis, S. G., O'Shaughnessy, C. D., Martin, S. L., Kent, K., McGarry, T., Turco, M. A., Kereiakes, D. J., Popma, J. J., Friedman, M., Koglin, J., Stone, G. W., for the TAXUS V ISR Investigators, (2008). Two-year clinical outcomes after paclitaxel-eluting stent or brachytherapy treatment for bare metal stent restenosis: the TAXUS V ISR trial. Eur Heart J 29: 1625-1634 [Abstract] [Full Text]
Ferri, N., Granata, A., Pirola, C., Torti, F., Pfister, P. J., Dorent, R., Corsini, A. (2008). Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle Cells by Altering p27Kip1/Cyclin E Expression. Mol. Pharmacol. 74: 144-153 [Abstract] [Full Text]
Malenka, D. J., Kaplan, A. V., Lucas, F. L., Sharp, S. M., Skinner, J. S. (2008). Outcomes Following Coronary Stenting in the Era of Bare-Metal vs the Era of Drug-Eluting Stents. JAMA 299: 2868-2876 [Abstract] [Full Text]
Meimoun, P., Benali, T., Elmkies, F., Sayah, S., Luycx-Bore, A., Doutrelan, L., Hamdane, Z., Boulanger, J., Tribouilloy, C. (2008). Prognostic value of transthoracic coronary flow reserve in medically treated patients with proximal left anterior descending artery stenosis of intermediate severity. Eur J Echocardiogr 0: jen190v1-6 [Abstract] [Full Text]
Alfonso, F. (2008). The "vulnerable" stent why so dreadful?. J Am Coll Cardiol 51: 2403-2406 [Full Text]
Dixon, S. R., Grines, C. L., O'Neill, W. W. (2008). The year in interventional cardiology.. J Am Coll Cardiol 51: 2355-2369 [Full Text]
Brar, S. S., Kim, J., Brar, S. K., Zadegan, R., Ree, M., Liu, I.-L. A., Mansukhani, P., Aharonian, V., Hyett, R., Shen, A. Y.-J. (2008). Long-term outcomes by clopidogrel duration and stent type in a diabetic population with de novo coronary artery lesions.. J Am Coll Cardiol 51: 2220-2227 [Abstract] [Full Text]
Austin, D., Pell, J. P., Oldroyd, K. G., Agostoni, P., Vermeersch, P., Marroquin, O. C., Mulukutla, S. R., Kip, K. E. (2008). Bare-Metal versus Drug-Eluting Coronary Stents. NEJM 358: 2516-2518 [Full Text]
Hamilos, M. I., Ostojic, M., Beleslin, B., Sagic, D., Mangovski, L., Stojkovic, S., Nedeljkovic, M., Orlic, D., Milosavljevic, B., Topic, D., Karanovic, N., Wijns, W., on behalf of the NOBORI CORE Investigators, (2008). Differential effects of drug-eluting stents on local endothelium-dependent coronary vasomotion.. J Am Coll Cardiol 51: 2123-2129 [Abstract] [Full Text]
Austin, D., Oldroyd, K. G., McConnachie, A., Slack, R., Eteiba, H., Flapan, A. D., Jennings, K. P., Northcote, R. J., Pell, A. C. H., Starkey, I. R., Pell, J. P. (2008). Hospital and operator variations in drug-eluting stent use: a multi-level analysis of 5967 consecutive patients in Scotland. J Public Health (Oxf) 30: 186-193 [Abstract] [Full Text]
Li, J., Jabara, R., Pendyala, L., Otsuka, Y., Shinke, T., Hou, D., Robinson, K., Chronos, N. (2008). Abnormal Vasomotor Function of Porcine Coronary Arteries Distal to Sirolimus-Eluting Stents. J Am Coll Cardiol Intv 1: 279-285 [Abstract] [Full Text]
Becker, R. C., Meade, T. W., Berger, P. B., Ezekowitz, M., O'Connor, C. M., Vorchheimer, D. A., Guyatt, G. H., Mark, D. B., Harrington, R. A. (2008). The Primary and Secondary Prevention of Coronary Artery Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 776S-814S [Abstract] [Full Text]
Kelbaek, H., Klovgaard, L., Helqvist, S., Lassen, J. F., Krusell, L. R., Engstrom, T., Botker, H. E., Jorgensen, E., Saunamaki, K., Aljabbari, S., Thayssen, P., Galloe, A., Jensen, G. V.H., Thuesen, L. (2008). Long-Term Outcome in Patients Treated With Sirolimus-Eluting Stents in Complex Coronary Artery Lesions: 3-Year Results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) Trial. J Am Coll Cardiol 51: 2011-2016 [Abstract] [Full Text]
Groeneveld, P. W., Matta, M. A., Greenhut, A. P., Yang, F. (2008). Drug-Eluting Compared With Bare-Metal Coronary Stents Among Elderly Patients. J Am Coll Cardiol 51: 2017-2024 [Abstract] [Full Text]
Garg, P., Cohen, D. J., Gaziano, T., Mauri, L. (2008). Balancing the Risks of Restenosis and Stent Thrombosis in Bare-Metal Versus Drug-Eluting Stents: Results of a Decision Analytic Model. J Am Coll Cardiol 51: 1844-1853 [Abstract] [Full Text]
Bhatt, S. H, Hauser, T. H (2008). Very Late Stent Thrombosis After Dual Antiplatelet Therapy Discontinuation in a Patient with a History of Acute Stent Thrombosis. The Annals of Pharmacotherapy 42: 708-712 [Abstract] [Full Text]
Moens, A. L., Vrints, C. J., Claeys, M. J., Timmermans, J.-P., Champion, H. C., Kass, D. A. (2008). Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease. Am. J. Physiol. Heart Circ. Physiol. 294: H1971-H1977 [Abstract] [Full Text]
Wallentin, L. (2008). Dual antiplatelet therapy in the drug-eluting stent era. Eur Heart J Suppl 10: D38-D44 [Abstract] [Full Text]
Stone, G. W., Midei, M., Newman, W., Sanz, M., Hermiller, J. B., Williams, J., Farhat, N., Mahaffey, K. W., Cutlip, D. E., Fitzgerald, P. J., Sood, P., Su, X., Lansky, A. J., for the SPIRIT III Investigators, (2008). Comparison of an Everolimus-Eluting Stent and a Paclitaxel-Eluting Stent in Patients With Coronary Artery Disease: A Randomized Trial. JAMA 299: 1903-1913 [Abstract] [Full Text]
Di Mario, C., Barlis, P. (2008). Optical Coherence Tomography: A New Tool to Detect Tissue Coverage in Drug-Eluting Stents. J Am Coll Cardiol Intv 1: 174-175 [Full Text]
Zellweger, M. J., Kaiser, C., Brunner-La Rocca, H. P., Buser, P. T., Osswald, S., Weiss, P., Mueller-Brand, J., Pfisterer, M. E., for the BASKET Investigators, (2008). Value and Limitations of Target-Vessel Ischemia in Predicting Late Clinical Events After Drug-Eluting Stent Implantation. JNM 49: 550-556 [Abstract] [Full Text]
Salanti, G., Kavvoura, F. K., Ioannidis, J. P.A. (2008). Exploring the Geometry of Treatment Networks. ANN INTERN MED 148: 544-553 [Abstract] [Full Text]
Godet, G., Le Manach, Y., Lesache, F., Perbet, S., Coriat, P. (2008). Drug-eluting stent thrombosis in patients undergoing non-cardiac surgery: is it always a problem?. Br J Anaesth 100: 472-477 [Abstract] [Full Text]
Billinger, M., Beutler, J., Taghetchian, K. R., Remondino, A., Wenaweser, P., Cook, S., Togni, M., Seiler, C., Stettler, C., Eberli, F. R., Luscher, T. F., Wandel, S., Juni, P., Meier, B., Windecker, S. (2008). Two-year clinical outcome after implantation of sirolimus-eluting and paclitaxel-eluting stents in diabetic patients. Eur Heart J 29: 718-725 [Abstract] [Full Text]
Kirtane, A. J., Ellis, S. G., Dawkins, K. D., Colombo, A., Grube, E., Popma, J. J., Fahy, M., Leon, M. B., Moses, J. W., Mehran, R., Stone, G. W. (2008). Paclitaxel-Eluting Coronary Stents in Patients With Diabetes Mellitus Pooled Analysis From 5 Randomized Trials.. J Am Coll Cardiol 51: 708-715 [Abstract] [Full Text]
Ortolani, P., Balducelli, M., Marzaroli, P., Piovaccari, G., Menozzi, A., Guiducci, V., Sangiorgio, P., Tarantino, F., Geraci, G., Castriota, F., Tondi, S., Saia, F., Cooke, R. M.T., Guastaroba, P., Grilli, R., Marzocchi, A., Maresta, A. (2008). Two-Year Clinical Outcomes With Drug-Eluting Stents for Diabetic Patients With De Novo Coronary Lesions: Results From a Real-World Multicenter Registry. Circulation 117: 923-930 [Abstract] [Full Text]
Applegate, R. J., Sacrinty, M. T., Kutcher, M. A., Santos, R. M., Gandhi, S. K., Baki, T. T., Little, W. C. (2008). "Off-label" stent therapy 2-year comparison of drug-eluting versus bare-metal stents.. J Am Coll Cardiol 51: 607-614 [Abstract] [Full Text]
Jeremias, A., Kirtane, A. (2008). Balancing Efficacy and Safety of Drug-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention. ANN INTERN MED 148: 234-238 [Abstract] [Full Text]
Saia, F., Marzocchi, A., Branzi, A. (2008). Review: The safety of drug-eluting stents. Therapeutic Advances in Cardiovascular Disease 2: 43-52 [Abstract]
Austin, D., Pell, J. P, Oldroyd, K. G (2008). Drug-eluting stents: do the risks really outweigh the benefits?. Heart 94: 127-128 [Full Text]
Melikian, N, Wijns, W (2008). Drug-eluting stents: a critique. Heart 94: 145-152 [Abstract] [Full Text]
Holmes, D. R. Jr, Gersh, B. J., Whitlow, P., King, S. B. III, Dove, J. T. (2008). Percutaneous Coronary Intervention for Chronic Stable Angina: A Reassessment. J Am Coll Cardiol Intv 1: 34-43 [Abstract] [Full Text]
Marroquin, O. C., Selzer, F., Mulukutla, S. R., Williams, D. O., Vlachos, H. A., Wilensky, R. L., Tanguay, J.-F., Holper, E. M., Abbott, J. D., Lee, J. S., Smith, C., Anderson, W. D., Kelsey, S. F., Kip, K. E. (2008). A Comparison of Bare-Metal and Drug-Eluting Stents for Off-Label Indications. NEJM 358: 342-352 [Abstract] [Full Text]
Carrozza, J. P. Jr. (2008). Drug-Eluting Stents -- Pushing the Envelope beyond the Labels?. NEJM 358: 405-407 [Full Text]
American College of Cardiology/American Heart Asso, , 2007 Writing Group to Review New Evidence and Upda, , King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention. J Am Coll Cardiol 51: 172-209 [Full Text]
King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O., 2005 WRITING COMMITTEE MEMBERS, , Smith, S. C. Jr, Feldman, T. E., Hirshfeld, J. W. Jr, Jacobs, A. K., Kern, M. J., King, S. B. III, Morrison, D. A., O'Neill, W. W., Schaff, H. V., Whitlow, P. L., Williams, D. O., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Buller, C. E., Creager, M. A., Ettinger, S. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence and Update the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention, Writing on Behalf of the 2005 Writing Committee. Circulation 117: 261-295 [Full Text]
Desai, N. D. (2008). Pitfalls Assessing the Role of Drug-Eluting Stents in Multivessel Coronary Disease. Ann. Thorac. Surg. 85: 25-27 [Full Text]
Martin, K. A., Merenick, B. L., Ding, M., Fetalvero, K. M., Rzucidlo, E. M., Kozul, C. D., Brown, D. J., Chiu, H. Y., Shyu, M., Drapeau, B. L., Wagner, R. J., Powell, R. J. (2007). Rapamycin Promotes Vascular Smooth Muscle Cell Differentiation through Insulin Receptor Substrate-1/Phosphatidylinositol 3-Kinase/Akt2 Feedback Signaling. J. Biol. Chem. 282: 36112-36120 [Abstract] [Full Text]
Unger, F. (2007). Drug eluting stents a nightmare?. ICVTS 6: 813-814 [Abstract] [Full Text]
Abbott, J. D., Voss, M. R., Nakamura, M., Cohen, H. A., Selzer, F., Kip, K. E., Vlachos, H. A., Wilensky, R. L., Williams, D. O. (2007). Unrestricted Use of Drug-Eluting Stents Compared With Bare-Metal Stents in Routine Clinical Practice: Findings From the National Heart, Lung, and Blood Institute Dynamic Registry. J Am Coll Cardiol 50: 2029-2036 [Abstract] [Full Text]
Buttner, H. J., Neumann, F.-J. (2007). Peeling-Off Labels: Mounting Evidence for Benefit of Drug-Eluting Stents With Off-Label Use. J Am Coll Cardiol 50: 2037-2038 [Full Text]
Williams, D. O., Abbott, J. D. (2007). Et Tu, Bare Metal Stent?. Circulation 116: 2363-2365 [Full Text]
Doyle, B., Rihal, C. S., O'Sullivan, C. J., Lennon, R. J., Wiste, H. J., Bell, M., Bresnahan, J., Holmes, D. R. Jr (2007). Outcomes of Stent Thrombosis and Restenosis During Extended Follow-Up of Patients Treated With Bare-Metal Coronary Stents. Circulation 116: 2391-2398 [Abstract] [Full Text]
Colombo, A. (2007). Directional Coronary Atherectomy and Implantation of Drug-Eluting Stents in Selected Bifurcation Lesions: A Logical Combination Waiting Evidence. J Am Coll Cardiol 50: 1946-1947 [Full Text]
Lamas, G. A, Hochman, J. S (2007). Where does the Occluded Artery Trial leave the late open artery hypothesis?. Heart 93: 1319-1321 [Abstract] [Full Text]
Wilson, G. J., Polovick, J. E., Huibregtse, B. A., Poff, B. C. (2007). Overlapping paclitaxel-eluting stents: Long-term effects in a porcine coronary artery model. Cardiovasc Res 76: 361-372 [Abstract] [Full Text]
Fleisher, L. A., Beckman, J. A., Brown, K. A., Calkins, H., Chaikof, E. L., Fleischmann, K. E., Freeman, W. K., Froehlich, J. B., Kasper, E. K., Kersten, J. R., Riegel, B., Robb, J. F., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Buller, C. E., Creager, M. A., Ettinger, S. M., Faxon, D. P., Fuster, V., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2007). ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol 50: e159-e242 [Full Text]
Windecker, S., Meier, B. (2007). Late Coronary Stent Thrombosis. Circulation 116: 1952-1965 [Full Text]
Fleisher, L. A., Beckman, J. A., Brown, K. A., Calkins, H., Chaikof, E. L., Fleischmann, K. E., Freeman, W. K., Froehlich, J. B., Kasper, E. K., Kersten, J. R., Riegel, B., Robb, J. F. (2007). ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation 116: e418-e500 [Full Text]
Kereiakes, D. J., Mauri, L., Kuntz, R. E. (2007). Letter by Kereiakes et al Regarding Article, "Stent Thrombosis Late After Implantation of First-Generation Drug-Eluting Stents: A Cause for Concern". Circulation 116: e389-e389 [Full Text]
Strom, A., Wigren, M., Hultgardh-Nilsson, A., Saxena, A., Gomez, M. F., Cardell, S., Fredrikson, G. N., Nilsson, J. (2007). Involvement of the CD1d Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury. Circ. Res. 101: e83-e89 [Abstract] [Full Text]
Tu, J. V., Bowen, J., Chiu, M., Ko, D. T., Austin, P. C., He, Y., Hopkins, R., Tarride, J.-E., Blackhouse, G., Lazzam, C., Cohen, E. A., Goeree, R. (2007). Effectiveness and Safety of Drug-Eluting Stents in Ontario. NEJM 357: 1393-1402 [Abstract] [Full Text]
Farag, N., Delbanco, T., Carrozza, J. P. Jr (2007). Update: A 69-Year-Old Woman With Left Main Coronary Artery Disease. JAMA 298: 1558-1559 [Full Text]
Chassot, P.-G., Delabays, A., Spahn, D. R. (2007). Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction. Br J Anaesth 99: 316-328 [Abstract] [Full Text]
Daemen, J., Serruys, P. W. (2007). Drug-Eluting Stent Update 2007: Part II: Unsettled Issues. Circulation 116: 961-968 [Full Text]
Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: e1-e157 [Full Text]
Bavry, A. A., Bhatt, D. L. (2007). Drug-Eluting Stents: Dual Antiplatelet Therapy for Every Survivor?. Circulation 116: 696-699 [Full Text]
Bode, C., Zehender, M. (2007). The use of antiplatelet agents following percutaneous coronary intervention: focus on late stent thrombosis. Eur Heart J Suppl 9: D10-D19 [Abstract] [Full Text]
Jensen, L. O., Maeng, M., Kaltoft, A., Thayssen, P., Hansen, H. H. T., Bottcher, M., Lassen, J. F., Krussel, L. R., Rasmussen, K., Hansen, K. N., Pedersen, L., Johnsen, S. P., Soerensen, H. T., Thuesen, L. (2007). Stent Thrombosis, Myocardial Infarction, and Death After Drug-Eluting and Bare-Metal Stent Coronary Interventions. J Am Coll Cardiol 50: 463-470 [Abstract] [Full Text]

Comments and questions? Please contact us.