FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

FOCUS ON RESEARCH Previous Volume 356:1094-1097 March 15, 2007 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Perspective Editorial by Lupski, J. R. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Lupski, J. R. PubMed Citation

As researchers have explored the environmental and inherited causes of common diseases, they have often amassed clinical and laboratory data collected from people with common complex disorders. Many have also collected biologic material, including DNA. These resources represent an essential component for ferreting out genes relevant to disease with the use of the genome-wide association study. This method entails the matching of a given human genome sequence with an annotated, high-resolution map of common genetic variation; it benefits from a large collection of DNA samples obtained from a population whose clinical characteristics are well defined, as well as cost-effective genotyping . . . [Full Text of this Article]

Source Information

Dr. Christensen is a professor of epidemiology at the University of Southern Denmark, Odense, Denmark. Dr. Murray is a professor of pediatrics, biology, and public health at the University of Iowa, Iowa City.

This article has been cited by other articles:

• Adegbola, M. A. (2009). Can Heterogeneity of Chronic Sickle-Cell Disease Pain Be Explained by Genomics? A Literature Review. Biol Res Nurs 11: 81-97 [Abstract]  
• Gao, L., Barnes, K. C. (2009). Recent advances in genetic predisposition to clinical acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L713-L725 [Abstract] [Full Text]  
• Dagle, J. M., Lepp, N. T., Cooper, M. E., Schaa, K. L., Kelsey, K. J.P., Orr, K. L., Caprau, D., Zimmerman, C. R., Steffen, K. M., Johnson, K. J., Marazita, M. L., Murray, J. C. (2009). Determination of Genetic Predisposition to Patent Ductus Arteriosus in Preterm Infants. Pediatrics 123: 1116-1123 [Abstract] [Full Text]  
• Huang, R. S., Ratain, M. J. (2009). Pharmacogenetics and pharmacogenomics of anticancer agents. CA Cancer J Clin 59: 42-55 [Abstract] [Full Text]  
• Miyairi, I., DeVincenzo, J. P. (2008). Human Genetic Factors and Respiratory Syncytial Virus Disease Severity. Clin. Microbiol. Rev. 21: 686-703 [Abstract] [Full Text]  
• Watkins, H, Ashrafian, H, McKenna, W J (2008). The genetics of hypertrophic cardiomyopathy: Teare redux. Heart 94: 1264-1268 [Full Text]  
• Leiman, D. A., Lorenzi, N. M., Wyatt, J. C., Doney, A. S.F., Rosenbloom, S. T. (2008). US and Scottish Health Professionals' Attitudes toward DNA Biobanking. J. Am. Med. Inform. Assoc. 15: 357-362 [Abstract] [Full Text]  
• Pearson, T. A., Manolio, T. A. (2008). How to Interpret a Genome-wide Association Study. JAMA 299: 1335-1344 [Abstract] [Full Text]  
• Ridker, P. M, Chasman, D. I., Zee, R. Y.L., Parker, A., Rose, L., Cook, N. R., Buring, J. E, for the Women's Genome Health Study Working Group, (2008). Rationale, Design, and Methodology of the Women's Genome Health Study: A Genome-Wide Association Study of More Than 25 000 Initially Healthy American Women. Clin. Chem. 54: 249-255 [Abstract] [Full Text]  
• Merialdi, M., Murray, J. C. (2007). The Changing Face of Preterm Birth. Pediatrics 120: 1133-1134 [Full Text]  
• Burke, W., Psaty, B. M. (2007). Personalized Medicine in the Era of Genomics. JAMA 298: 1682-1684 [Full Text]  
• Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., Barrett, J. H., Konig, I. R., Stevens, S. E., Szymczak, S., Tregouet, D.-A., Iles, M. M., Pahlke, F., Pollard, H., Lieb, W., Cambien, F., Fischer, M., Ouwehand, W., Blankenberg, S., Balmforth, A. J., Baessler, A., Ball, S. G., Strom, T. M., Braenne, I., Gieger, C., Deloukas, P., Tobin, M. D., Ziegler, A., Thompson, J. R., Schunkert, H., the WTCCC and the Cardiogenics Consortium, (2007). Genomewide Association Analysis of Coronary Artery Disease. NEJM 357: 443-453 [Abstract] [Full Text]  
• Hunter, D. J., Kraft, P. (2007). Drinking from the Fire Hose -- Statistical Issues in Genomewide Association Studies. NEJM 357: 436-439 [Full Text]  
• Greist, J. H., Jefferson, J. W. (2007). Obsessive-Compulsive Disorder. Focus 5: 283-298 [Abstract] [Full Text]