To the Editor: A positive test for the presence of human chorionicgonadotropin (hCG) before menopause is an indication of pregnancy.1A positive hCG test in menopausal women poses a diagnostic challenge,despite available guidance in the literature.1,2 Erroneous assumptionsregarding the presence of cancer have led to costly diagnostictesting, delays in necessary treatment, and even the initiationof toxic cancer treatments.
Pituitary production of hCG was first demonstrated 30 yearsago, and many contemporary reports indicate that the pituitaryproduces hCG.1,2,3,4 Low levels of hCG accompany the midcyclepreovulatory surge of luteinizing hormone,1,2,3,4 and pituitaryhCG is normally . . . [Full Text of this Article]
This article has been cited by other articles:
de Medeiros, S.F., Norman, R.J.
(2009). Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights. Hum Reprod Update
15: 69-95
[Abstract][Full Text]
Ballieux, B. E.P.B., Weijl, N. I., Gelderblom, H., van Pelt, J., Osanto, S.
(2008). False-Positive Serum Human Chorionic Gonadotropin (hCG) in a Male Patient with a Malignant Germ Cell Tumor of the Testis: A Case Report and Review of the Literature. The Oncologist
13: 1149-1154
[Abstract][Full Text]
Gronowski, A. M., Fantz, C. R., Parvin, C. A., Sokoll, L. J., Wiley, C. L., Wener, M. H., Grenache, D. G.
(2008). Use of Serum FSH to Identify Perimenopausal Women with Pituitary hCG. Clin. Chem.
54: 652-656
[Abstract][Full Text]
McCudden, C. R., Willis, M. S., Grenache, D. G.
(2008). Persistent Low Concentration of Human Chorionic Gonadotropin in a Nonpregnant Woman. Clin. Chem.
54: 209-213
[Full Text]
Lempiainen, A., Hotakainen, K., Blomqvist, C., Alfthan, H., Stenman, U.-H.
(2007). Increased Human Chorionic Gonadotropin Due to Hypogonadism after Treatment of a Testicular Seminoma. Clin. Chem.
53: 1560-1561
[Full Text]