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Volume 356:1269-1271 March 22, 2007 Number 12
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Peginterferon and Ribavirin for Hepatitis C

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 by Hoofnagle, J. H.
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To the Editor: In their review of peginterferon and ribavirin for the treatment of hepatitis C, Hoofnagle and Seeff (Dec. 7 issue)1 do not include data on the association between the consumption of alcohol and both treatment response and disease progression. Level-one evidence of the deleterious effects of alcohol on hepatitis C virus (HCV) RNA levels, on the response to treatment, and on disease progression led the National Institutes of Health and the American Gastroenterological Association to issue position statements advising that "abstinence should be recommended before and during antiviral treatment . . . [since] even moderate alcohol consumption can have a . . . [Full Text of this Article]




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