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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the authors' clinical recommendations.
A 64-year-old man presents to his internist for his annual examination. He has been in good general health, although he received a diagnosis of pneumonia 8 months ago, for which he was treated with a course of oral antibiotics.
The Clinical Problem
Pathophysiology and Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Departments of Pediatrics (D.W.K.) and Pediatrics, Microbiology, Medicine, and Neurosurgery (R.J.W.), University of Alabama at Birmingham, Birmingham.
Address reprint requests to Dr. Kimberlin at the Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, 1600 Seventh Ave. S., CHB 303, Birmingham, AL 35233, or at dkimberlin@peds.uab.edu.
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N Engl J Med 2007;
357:88-90, Jul 5, 2007.
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