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Correspondence
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Volume 356:1583-1585 April 12, 2007 Number 15
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Childhood Progression of Hereditary Medullary Thyroid Cancer

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 by Machens, A.
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To the Editor: Machens et al. (Oct. 16, 2003, issue)1 confirmed that medullary thyroid carcinoma develops very early in children carrying a germ-line mutation of the rearranged during transfection (RET) gene. However, an error in Figure 1 of their article may alter the message of this important article. According to Figure 1, the risk of medullary thyroid carcinoma for a child with a codon 634 RET mutation is approximately 10% at 5 years of age. This finding seems to be inconsistent with the data provided by Machens et al.: that 75% of children with a codon 634 RET . . . [Full Text of this Article]




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