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Correspondence
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Volume 356:1591-1592 April 12, 2007 Number 15
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Fatal Reactivation of Hepatitis B with Temozolomide

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To the Editor: Encouraging results have led to the use of temozolomide as a first-line therapy for glioblastoma.1 We report on a case of temozolomide-associated reactivation of hepatitis B, a complication that may warrant the use of prophylactic antiviral agents during treatment with this chemotherapy.2

A 65-year-old Chinese woman with a remote history of hepatitis B underwent total surgical resection of an enhancing mass in the left temporal lobe, which was diagnosed as glioblastoma. She received radiation therapy with concurrent daily temozolomide (at a dose of 75 mg per square meter of body-surface area), followed by three cycles of adjuvant . . . [Full Text of this Article]


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