Blood transfusion has for years been considered to have obviousclinical benefits and to be a relatively low-risk procedure.Not until the early 1980s did transfusion practices begin tocome under systematic scrutiny. Initially, this trend was drivenby concern about transfusion-related infection, particularlyby human immunodeficiency virus, but advances in transfusionmedicine have greatly decreased the risk of transmission ofviruses by transfused blood. Now, other concerns — theeffects of transfusion on the immune system, transfusion-relatedacute lung injury, and the age of transfused blood — drivethe debate over transfusion practice and have led to methodicalexaminations . . . [Full Text of this Article]
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From the Section of Critical Care Medicine, Dartmouth–Hitchcock Medical Center, Lebanon, NH (H.L.C.); and the Division of General Internal Medicine, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick (J.L.C.).
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