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Previous Volume 356:1680 April 19, 2007 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Imboden et al. (Dec. 28 issue)¹ report preferential transmission of mutant alleles in the KCNQ1 gene (11p15.5) from mothers to daughters and propose that these mutations confer a selective reproductive advantage. However, allele-specific transmission-ratio distortion² and grandparental-origin–dependent transmission-ratio distortion³ have been described previously for 11p15.5.^2,3 Specifically, the 11p15.5 alleles of a maternal grandmother are more likely (61%) to be transmitted to her granddaughters than to her grandsons.³ The transmission of 11p15.5 alleles that is dependent on their grandparental origin is consistent with these observations.¹ Indeed, if females are more likely to be affected, the mutant KCNQ1 alleles . . . [Full Text of this Article]

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