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Volume 356:1684-1685 April 19, 2007 Number 16
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Antibiotic Prophylaxis in Colorectal Surgery

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by Itani, K. M.F.
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To the Editor: Fifteen years ago, Martin et al. showed that when a single intravenous dose of 2 g of cefotetan was administered to patients immediately before colorectal surgery, adequate concentrations of cefotetan in both the blood and colonic wall were maintained during surgical anastomosis (for a mean [±SD] period of 151±54 minutes) and throughout surgery.1 These concentrations of cefotetan remained superior to the minimum inhibitory concentrations of the drug for 90% of Staphylococcus aureus (16.0 mg per liter), Escherichia coli (0.05 mg per liter), and Bacteroides fragilis (8.0 mg per liter). However, concentrations of cefotetan in the abdominal wall . . . [Full Text of this Article]



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