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A 46-year-old woman came to the Center for Cancer Risk Analysis at the Cancer Center of this hospital because of recent diagnoses of endometrial, ovarian, and colonic cancers.
Fifteen weeks earlier, a routine Papanicolaou smear showed an atypical glandular cell, and she was referred to a gynecologist at this hospital. Fifteen years earlier, the patient had had abnormal findings on a Pap smear performed elsewhere; the uterine cervix was treated with cryotherapy. Over the next 14 years, repeated Papanicolaou smears were normal. She had had four early miscarriages at 6 to 8 weeks' gestation. Her menses were normal and regular.
Differential Diagnosis
Dr. Michael V. Seiden's Diagnosis
Pathological Discussion
Discussion of Management
Recommendations for a Patient with HNPCC
Recommendations for Family Members of Patients with HNPCC
Anatomical Diagnosis
Source Information
From the Department of Medicine (M.V.S.), the Center for Cancer Risk Analysis (D.P.), the Department of Radiology (M.J.O.), and the Department of Pathology (E.O.), Massachusetts General Hospital; and the Departments of Medicine (M.V.S.), Radiology (M.J.O.), and Pathology (E.O.), Harvard Medical School.
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