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Previous Volume 356:1771-1773 April 26, 2007 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Bipolar disorder consists of depressive episodes of low mood, difficulty in concentration and work, poor sleep, and poor appetite, as well as distinct manic episodes of expansive mood, pressured speech, overactivity, sexual excesses, aggressiveness, and little need for sleep; both types of episode may last for weeks or months. The primary goal of treatment is the prevention of these episodes with the use of mood stabilizers such as lithium, valproate, carbamazepine, and lamotrigine and some of the new atypical antipsychotic drugs such as olanzapine or quetiapine. However, when prophylaxis fails and a depressive or manic episode occurs, questions of appropriate . . . [Full Text of this Article]

Source Information

From Ben Gurion University and Beersheva Mental Health Center — both in Beersheva, Israel.

This article (10.1056/NEJMe078042) was published at www.nejm.org on March 28, 2007.

Related Letters:

Adjunctive Antidepressant Treatment for Bipolar Depression
Price L. H., Tyrka A. R., Henry C., Demotes-Mainard J., Leboyer M., El-Mallakh R. S., Sachs G. S., Bowden C., Thase M. E.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:614-616, Aug 9, 2007. Correspondence

This article has been cited by other articles:

• Saddichha, S., Kumar, D. (2007). Is Psychosocial Management Effective?. Arch Gen Psychiatry 64: 1451-1451 [Full Text]  
• Price, L. H., Tyrka, A. R., Henry, C., Demotes-Mainard, J., Leboyer, M., El-Mallakh, R. S., Sachs, G. S., Bowden, C., Thase, M. E. (2007). Adjunctive Antidepressant Treatment for Bipolar Depression. NEJM 357: 614-616 [Full Text]