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Correspondence
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Volume 356:1779-1780 April 26, 2007 Number 17
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Familial Hypercholesterolemia

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by Cuchel, M.
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To the Editor: Cuchel and colleagues (Jan. 11 issue)1 report that inhibition of the microsomal triglyceride transfer protein reduces plasma low-density lipoprotein (LDL) cholesterol in homozygous familial hypercholesterolemia — a finding that establishes the value of targeting this enzyme and provides hope for patients with this condition. Treatment-related hepatic steatosis was predictable from studies in animals,2 variable among study subjects, and reversible with discontinuation of the inhibitor. Although the long-term consequences of sustained hepatic steatosis are unclear, some clues might be found among genetic-deficiency states associated with the microsomal triglyceride transfer protein, in particular in patients with abetalipoproteinemia. For instance, . . . [Full Text of this Article]



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