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Previous Volume 356:1781-1782 April 26, 2007 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the report by Wang et al. (July 20 issue)¹ about mutant neurogenin-3 in patients with congenital malabsorptive diarrhea, patients with the R93L and R107S mutations of the neurogenin-3 gene (NEUROG3) had congenital diarrhea and sparse enteroendocrine cells. They did not have diabetes at birth and, by inference, had insulin-producing cells in the islets of Langerhans. In contrast, mice deficient in Neurog3 have neonatal diabetes due to a total lack of beta cells.² Wang et al. therefore suggest that a putative unidentified factor can partially compensate for a lack of NEUROG3 in the developing human . . . [Full Text of this Article]

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